Vaginal yeast infections are common, in fact it is normal to have up to 3 a year. They are irritating and inconvenient so I totally understand why people would look for ways to A) prevent them B) soothe the irritation of an infection while you are waiting for medication to kick in. It is also easy to see how, given the number of infections experienced annually, big business wants in on that action. 

Prevention and soothing yeast infections is exactly what AZO Yeast ® promises. In fact, it says so right on the website: Use three times a day to relieveproduct_large_yeast symptoms of a vaginal yeast infection. Use once daily to help prevent recurrence of vaginal yeast infection symptoms.

First of all, there are no studies in PubMed looking at the efficacy of AZO Yeast® for either of these claims. So let’s look at the product a little further.

It claims to be a homeopathic medicine, which is the very definition of oxymoron as homeopathy is not consistent with any known scientific principles and medicine is a science. This should be a red flag to anyone. The National Center for Complementary and Alternative Medicine (NCCAM) has nothing good to say about homeopathy and there are no studies that have shown homeopathy to be effective for anything.

But I’m always open to learn, so let’s break down the ingredients of AZO Yeast®:

  • Mistletoe leaf (Viscum album) 5X: There are no published studies looking at mistletoe leaf for vaginal yeast infections. The National Center for Complementary and Alternative Medicine (NCCAM) does not list vaginal yeast as one of the reported uses of this plant.
  • Boneset (Eupatorium perfoliatum) 5X: There are no published studies looking at boneset for vaginal yeast infections. NCCAM doesn’t even have a listing for Boneset or Eupatorium perfoliatum.

So the active ingredients are not proven to be fungicidal or fungistatic (i.e. effective against yeast). Can they prevent yeast by keeping the delicate vaginal ecosystem in balance? No. The probiotic base is bacillus coagulans, which is not a player in vaginal health. While there are some weak studies that suggest certain probiotics (lactobacillus rhamnosus and reuteri) might be helpful, these species are not in AZO Yeast®.  

Might you feel better if you use AZO Yeast® while you have an infection? Not unless you put it in your vagina ,although that is not how it is intended! The inactive ingredients include carnauba wax and fractionated coconut and palm kernel oils and products with waxes and oils can be soothing on irritated skin and inflamed vaginal mucosa, but again it’s an oral medication. As an aside, fractionating an oil is a process that increases the saturated fat to make it easier to use commercially and likely reduces the health benefits. Maybe it’s in a lot of medications, but we have learned from trans fats that altering/processing fats can promote inflammation so in general it is best to stay away from processed foods of all varieties.

If you want to feel better as fast as possible with a yeast infection there are much better options:

  • Take an antihistamine such as Zyrtec, Calritin, or Allegra. It will reduce the inflammation and definitely helps you feel better faster. A week is usually all that you need, but even one or two days might do it. Don’t use Benadryl (diphenhydramine), it’s not a great antihistamine.
  • Use a topical over the counter product for yeast, such as something with miconazole or clotrimazole. These are very soothing and so you get the immediate calming effect as well as the treatment. As an OB/GYN with a fellowship in infectious diseases this is my personal go to for the one-two punch of efficacy and immediate relief (hope that’s not TMI).
  • Apply some topical steroid at the vaginal opening and on the vulva twice a day for several days if these areas are inflamed.
  • Apply some zinc oxide externally to the vulva if it feels really inflamed and raw and you don’t have a steroid or don’t want to use that. You can also use A&D or Desitin. This is just to soothe external (vulvar) inflamed skin.
  • Never use anything with benzocaine. It is a potent allergen.

If you think this product worked for you before it was likely either placebo effect or simply the tincture of time (of you were using it to reduce symptoms of a current infection).

AZO Yeast® is an expensive way to take nothing of value. There are far better options for immediate relief. It also has no hope of preventing yeast. Really. If you want to try and prevent yeast, spend your money on products with lactobacillus rhamnosus and reuteri, the studies aren’t incredibly robust but at least we know those are the two important strains for vaginal health.

When it comes to AZO Yeast® just don’t waste your money.


Join the Conversation


  1. Homeopathy isn’t medicine at all! At best they are placebos and while placebos have some value, homeopathy has no real value except as a placebo. Thinking it could actually treat or cure anything is ridiculous especially if you read up on how it’s all so diluted it’s basically sugar pills or water, the best thing you can say about homeopathy is it cant hurt anyone.

  2. Oubli is right on; this is doubly worthless. The way homeopathic “strengths” (for lack of a better term) are expressed indicates that a 1:10 dilution- that’s the X- is repeated 5 times. So that becomes a 1:10^5 dilution, or 1:100,000. Unless these things are as strong as epinephrine, that concentration is unlikely to have any effect– and that’s assuming that those herbs actually do anything in the first place. Unlike more traditional homeopathic dilutions (involving a C, like 30C, indicating a 1:100 dilution repeated 30 times), there is a nonzero amount of the herb present. It’s just very, very close to zero. Amusingly, under the original Hahnemann principles of homeopathy, the concentration they produce would be viewed as much weaker than the 30C one, in which it’s nearly impossible that the package contains even a single molecule of the original substance. I guess they don’t want their product used to sabotage breweries.

  3. I would also like to see your thoughts on boric acid for yeast infections. Any thoughts on cytolytic vaginosis? this is almost more of a pain in the ass than having a yeast infection. My Gyno has me using baking soda as a treatment, but the damn imbalance just won’t go away.

  4. I’d like to know more about Benadryl being a poor antihistamine. I carry Benedryl in my purse in case I eat something cross-contaminated with shellfish in a restaurant. What antihistamine would be better?

  5. Great post. For my patients with chronic yeast infections we begin to dig a little deeper into their diet as well…watching carbs, refined sugars, fruits, etc. I do suggest they try a good vaginal probiotic with >50 billion bacteria count (Garden of Life) has a good brand and I can personally attest to it helping keep them at bay. I also have them ingest more cocounut oil as it has anti-fungal properties and is also very soothing to the inflamed tissue.

    I actually go to Diflucan vs vaginal creams more often than not-many patients including myself, experience extreme irritation and increased pain with topical applications. If the Diflucan fails, then I have had good success with boric acid. If they are pregnant, obviously we try the OTC creams. I am also a little weary about applying steroid creams to the area as this can cause the yeast to proliferate. Just some of my own personal observations in treating this pesky stuff.

    And one more random-I received a ton of antibiotics during the birth of my first child for GBS treatment-and a prolonged labor. So of course, post partum I came down with a horrible vaginal yeast infection on top of fresh stitches..horrible. At 3 am…my lovely midwife suggested I take a 1/4 cup of white distilled vinegar and mix in a cup of water and dab this on the area with a washcloth. The sting was strong but, within seconds I experienced amazing relief from the itching. Another one I throw out to others when needed:)

    Thanks for your posts-Amy Farmer CNM

  6. I used to use AZO, but i switched to the Lady Soma Cranberry Pills and I find them alot gentler and easier for my system. They also work 1 day faster than AZO for me. Whenever I have issues with antibiotics or other medications that leave me with a feeling of frequency and/or generalized discomfort, the Lady Soma Cranpberry supplements has always helped greatly, especially at night or anytime I have to sit for long

    1. I haven’t heard of cranberry pills having anything to do with treating or preventing yeast infections… Are you talking about UTI’s?

  7. The Azo Yeast ingredients were changed & I don’t understand it – but it now has Candida albicans in it. Wouldn’t that make a yeast infection worse?

    1. That’s exactly what I was thinking about!!! If it has Candida albicans, how can it heal the yeast infection? Anybody?

  8. Thank you for your medical sound article. Wish I didn’t waste my money on this product already.

  9. Thank you! Was about to go buy this product. Took amoxicillin for a sinus infection and have been MISERABLE since about day three. I knew the side effects of the antibiotic wouldn’t be worth. Wish I’d never taken it. Think I’ll try the clotrimazole and Zyrtec instead.

  10. AZO has an active ingredients that says Candida Albicans 30X, is the product giving me more of the virus?

  11. Thank you for this honest review. I bought Azo pills and wanted to know why they weren’t doing anything. My box says Candida albicans is in the pills? Why?

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